摘要：The title compound N-(2-(2-hydroxy-2-phenylacetyl)phenyl)cinnamamide(C23H19NO3,Mr=357.39)has been synthesized with 2-iodoaniline and ethynylbenzene as starting materials,and its crystal structure was determined by ^1H NMR,^13C NMR,H RMS and single-crystal X-ray diffraction for the first time.The crystal crystallizes in monoclinic system,space group P21/c with a=8.2850(7),b=25.934(2),c=8.3032(6)A,β=95.314(7)°,V=1776.4(3)A^3,Z=4,T=293(2)K,μ(Cu Kα)=0.71 mm^-1,Dc=1.336 Mg/cm3,3019 reflections measured(6.832≤2θ≤129.982°),2996 unique(Rint=0.0463,Rsigma=0.0549)which were used in all calculations.The final R=0.0880(I>2σ(I))and wR=0.2447(all data).The target compound has demonstrated weak or moderate anti-tumor activity against human leukemia k562 cell,human promyelocytic leukemia HL-60 cell,human gastric cancer line BGC-823,Hela cell and lung cancer A549 cell.
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